Contraindicated (one)pentobarbital will minimize the extent or impact of cariprazine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is answerable for the development and elimination of cariprazine's Lively metabolites.pentobarbital raises effects of ifosfamide by affecting hepatic enzyme CYP2B6 metabolism. Use War